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Combining Manufacturability and Quality by Design:
Potelligent® CHOK1SV Cell Line
Following the successful development of the Potelligent® CHOK1SV cell line by scientists at KHK and Lonza, the power of a Potelligent® mAb is available with the industry standard GS Gene Expression System™.
Potelligent® CHOK1SV cell line has similar properties to the parental CHOK1SV cell line and has been shown to produce entirely fucose-free antibodies with the expected ADCC enhancement.
Potelligent® CHOK1SV has undergone extensive trials in Lonza’s processes with a range of antibodies. A full range of protocols is available for the creation of highly productive cell lines.
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Evaluation of four Potelligent® CHOK1SV derived cell lines and two CHOK1SV derived cell lines, all producing the same antibody, in 10 L fed-batch bioreactor culture. In Lonza’s bioreactor process Potelligent® CHOK1SV demonstrated a similar range of growth and productivity characteristics to those achieved with the parental
CHOK1SV cell line. |
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